| First Author | Li M | Year | 2019 |
| Journal | Cell Mol Immunol | Volume | 16 |
| Issue | 9 | Pages | 757-769 |
| PubMed ID | 30705387 | Mgi Jnum | J:280573 |
| Mgi Id | MGI:6369932 | Doi | 10.1038/s41423-018-0185-x |
| Citation | Li M, et al. (2019) Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc. Cell Mol Immunol 16(9):757-769 |
| abstractText | Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity, but the underlying molecular mechanisms remain incompletely understood. In this study, Sin1, a key component of mTOR complex 2 (mTORC2), specifically regulates B cell growth and metabolism. Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism. Sin1 deficiency also severely impairs B-cell proliferation, antibody responses, and anti-viral immunity. At the molecular level, Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2, respectively. Therefore, our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. |
