| First Author | Hövelmeyer N | Year | 2014 |
| Journal | Eur J Immunol | Volume | 44 |
| Issue | 2 | Pages | 545-52 |
| PubMed ID | 24242374 | Mgi Jnum | J:208980 |
| Mgi Id | MGI:5565518 | Doi | 10.1002/eji.201343655 |
| Citation | Hovelmeyer N, et al. (2014) Overexpression of Bcl-3 inhibits the development of marginal zone B cells. Eur J Immunol 44(2):545-52 |
| abstractText | The transcription factor Bcl-3 functions as a proto-oncogene via regulation of cell proliferation and apoptosis. Bcl-3 is an atypical member of the IkappaB family and plays a central role in the immune response through interactions with the NF-kappaB subunits p50 and p52. To investigate the impact of Bcl-3 on B-cell maturation and regulation, we generated mice that overexpress Bcl-3 specifically in B cells. Interestingly, these mice lack marginal zone B cells and exhibit a significant reduction in the number of B-1 B cells. Further, B cells from these mice are impaired in their proliferative capacity. Our data demonstrate that the overexpression of the transcription factor Bcl-3 inhibits germinal center formation, marginal zone B-cell development, and affects the B-1 B-cell compartment. |
