| First Author | Cazac BB | Year | 2000 |
| Journal | Immunity | Volume | 13 |
| Issue | 4 | Pages | 443-51 |
| PubMed ID | 11070163 | Mgi Jnum | J:90558 |
| Mgi Id | MGI:3044144 | Doi | 10.1016/s1074-7613(00)00044-3 |
| Citation | Cazac BB, et al. (2000) TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity 13(4):443-51 |
| abstractText | To determine the role of the pleiotropic cytokine TGF-beta in B cells, we generated mice lacking the TGF-beta receptor (TbetaR) type II selectively in this cell type through conditional mutagenesis (Cre/loxP). The absence of TbetaRII in B cells leads to a reduced life span of conventional B cells, expansion of peritoneal B-1 cells, B cell hyperplasia in Peyer's patches, elevated serum immunoglobulin, and substantial IgG3 responses to a normally weak immunogen. This B cell hyperresponsiveness is associated with a virtually complete serum IgA deficiency. The data reveal differential roles of TbetaR in homeostasis and antigen responsiveness of B cell subpopulations and establish a critical function of the TGF-beta receptor ligand pair in the induction of IgA responses in vivo. |
