| First Author | Sanjo H | Year | 2007 |
| Journal | Mol Cell Biol | Volume | 27 |
| Issue | 4 | Pages | 1236-46 |
| PubMed ID | 17145771 | Mgi Jnum | J:118279 |
| Mgi Id | MGI:3699051 | Doi | 10.1128/MCB.01530-06 |
| Citation | Sanjo H, et al. (2007) Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G. Mol Cell Biol 27(4):1236-46 |
| abstractText | Activation of extracellular signal-regulated protein kinase (ERK) has been implicated in proliferation as well as differentiation in a wide variety of cell types. Using B-cell-specific gene-targeted mice, we report here that in T-cell-dependent immune responses, ERK2 is required to generate efficient immunoglobulin G (IgG) production. In its absence, the proportion of antigen-specific surface IgG1-bearing cells and the subsequent number of IgG1 antibody-secreting cells were decreased, despite apparently unimpaired class switch recombination. Notably, this defect was countered by overexpression of the antiapoptotic factor Bcl-2. Together, our results suggest that ERK2 plays a key role in efficient generation of antigen-specific IgG-bearing B cells by promoting their survival. |
