| First Author | Pasparakis M | Year | 2002 |
| Journal | J Exp Med | Volume | 196 |
| Issue | 6 | Pages | 743-52 |
| PubMed ID | 12235208 | Mgi Jnum | J:79132 |
| Mgi Id | MGI:2387265 | Doi | 10.1084/jem.20020907 |
| Citation | Pasparakis M, et al. (2002) IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med 196(6):743-52 |
| abstractText | Nuclear factor (NF)-kappaB proteins play crucial roles in immune responses and cellular survival. Activation of NF-kappaB is mediated by the IkappaB kinase (IKK) complex, which is composed of two kinases, IKK1 and IKK2, and a regulatory subunit termed NF-kappaB essential modulator (NEMO). IKK2- and NEMO-deficient mice die at early embryonic stages. We therefore used conditional gene targeting to evaluate the role of these proteins in B cells in adult mice. B lineage-specific disruption of either IKK signaling by deletion of NEMO, or of IKK2-specific signals by ablation of IKK2 activity leads to the disappearance of mature B lymphocytes. We conclude that maintenance of mature B cells depends on IKK-mediated activation of NF-kappaB. |
