| First Author | Winslow MM | Year | 2006 |
| Journal | Immunity | Volume | 24 |
| Issue | 2 | Pages | 141-52 |
| PubMed ID | 16473827 | Mgi Jnum | J:113318 |
| Mgi Id | MGI:3665386 | Doi | 10.1016/j.immuni.2005.12.013 |
| Citation | Winslow MM, et al. (2006) The calcineurin phosphatase complex modulates immunogenic B cell responses. Immunity 24(2):141-52 |
| abstractText | A series of signal-directed transitions regulates the development of distinct populations of self-tolerant B cells and ultimately the production of antibody-producing plasma cells. We studied the role of calcineurin/NFAT signaling in B cells by deleting the regulatory b1 subunit of calcineurin specifically in B cells. Follicular (FO) and marginal zone (MZ) B cells develop normally in these mice, but B1 cell numbers are reduced. In vitro, calcineurin b1-deficient B cells have a cell-intrinsic proliferation defect downstream of the B cell receptor. These mice have higher total serum IgM despite the absence of B1 cells and have enhanced T cell-independent-1 responses. Conversely, mice with calcineurin b1-deficient B cells develop larger germinal centers and have reduced plasma cell development and antigen-specific antibody production during T cell-dependent immune responses. By several different criteria, calcineurin is dispensable for B cell tolerance, indicating that this phosphatase complex modulates immunogenic, but not tolerogenic, responses in vivo. |
