| First Author | You Y | Year | 2009 |
| Journal | J Immunol | Volume | 182 |
| Issue | 12 | Pages | 7343-7 |
| PubMed ID | 19494255 | Mgi Jnum | J:149307 |
| Mgi Id | MGI:3848284 | Doi | 10.4049/jimmunol.0804295 |
| Citation | You Y, et al. (2009) Cutting edge: Primary and secondary effects of CD19 deficiency on cells of the marginal zone. J Immunol 182(12):7343-7 |
| abstractText | Marginal zone (MZ) B cells are absent in CD19(-/-) mice. Possible causes include an intrinsic defect in B cells and/or a secondary defect in the extrinsic MZ microenvironment as a result of changes in B cell differentiation in mice lacking CD19. Cells in the MZ also include MZ macrophages (MZM) and MZ dendritic cells (DC). Although CD19 is only expressed on B cells, SIGN-R1(+) MZM are absent and CD11c(+) MZ DC distribution is abnormal in CD19(-/-) mice. Adoptively transferred B cells from normal mice are able to reconstitute MZ B cells in CD19(-/-) mice. In contrast, CD19(-/-) B cells could not enter the MZ of the normal mice. Furthermore, MZM distribution and MZ DC distribution are restored following MZ B cell reconstitution in CD19(-/-) mice. Thus, MZ B cells are required for MZM differentiation and MZ DC localization, but the deficiency of MZ B cells in CD19(-/-) mice is caused by a defect of intrinsic B cell signaling. |
