| First Author | Lownik JC | Year | 2020 |
| Journal | Biochem Biophys Res Commun | Volume | 522 |
| Issue | 2 | Pages | 442-447 |
| PubMed ID | 31771880 | Mgi Jnum | J:293679 |
| Mgi Id | MGI:6453489 | Doi | 10.1016/j.bbrc.2019.11.124 |
| Citation | Lownik JC, et al. (2020) B cell ADAM17 controls T cell independent humoral immune responses through regulation of TACI and CD138. Biochem Biophys Res Commun 522(2):442-447 |
| abstractText | ADAM17 is known to contribute to the immune system through its shedding of tumor necrosis factor alpha (TNFalpha). However, the role of ADAM17 in B cell biology is not well characterized. To determine whether B cell ADAM17 contributes to T cell-independent humoral immune responses, we crossed CD19 Cre transgenic mice with mice bearing a floxed allele of ADAM17 (ADAM17(CD19)). In this study, we show a B cell intrinsic role for ADAM17 in regulating marginal zone B cell (MZB) numbers in mice. Interestingly, we demonstrate that the loss of B cell ADAM17 results in reduced MZB numbers in the naive state and after immunization with T-independent antigen, yet enhanced humoral immunity to T cell independent antigens. We additionally find elevated TACI and CD138 levels on plasma cells following immunization in ADAM17(CD19) mice. Overall, these findings suggest that B cell ADAM17 may orchestrate T independent immune responses through both MZB numbers and plasma cell antibody production. |
