| First Author | Won HY | Year | 2023 |
| Journal | J Autoimmun | Volume | 138 |
| Pages | 103059 | PubMed ID | 37216869 |
| Mgi Jnum | J:360766 | Mgi Id | MGI:7787274 |
| Doi | 10.1016/j.jaut.2023.103059 | Citation | Won HY, et al. (2023) Cytokine receptor gammac effectuates the generation of proinflammatory innate CD8 T cells by non-classical MHC-I molecules. J Autoimmun 138:103059 |
| abstractText | Innate CD8 T cells correspond to a population of terminally differentiated effector T cells that phenotypically appear as antigen-experienced memory cells and functionally resemble proinflammatory CD8 T cells, expressing copious amounts of IFNgamma. Innate CD8 T cells, however, are distinct from conventional effector-memory CD8 T cells as they acquire functional maturity during their generation in the thymus. Understanding the molecular mechanisms that drive their thymic development and differentiation is an intensely studied subject in T cell immunity, and here we identified the cytokine receptor gammac as a critical mediator of innate CD8 T cell generation that promotes their selection even in the absence of classical MHC-I molecules. Consequently, overexpression of gammac resulted in a dramatic increase of innate CD8 T cells in K(b)D(b)-deficient mice. We mapped its underlying mechanism to the expansion of IL-4-producing invariant NKT cells, so that it is the increased availability of intrathymic IL-4 which augments the selection of innate CD8 T cells. Collectively, these results unravel the selection of innate CD8 T cells being mediated by non-classical MHC-I molecules and being modulated by the abundance of the gammac cytokine, IL-4. |
