| First Author | Casellas R | Year | 2002 |
| Journal | Cell | Volume | 110 |
| Issue | 5 | Pages | 575-85 |
| PubMed ID | 12230975 | Mgi Jnum | J:111434 |
| Mgi Id | MGI:3653987 | Doi | 10.1016/s0092-8674(02)00911-x |
| Citation | Casellas R, et al. (2002) OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes. Cell 110(5):575-85 |
| abstractText | OcaB, a transcriptional coactivator also known as Bob-1 or OBF-1, was isolated on the basis of its ability to enhance transcription of immunoglobulin (Ig) genes in vitro. Paradoxically, OcaB(-/-) mice showed no apparent deficiency in Ig gene transcription, only cellular immune defects including absence of germinal centers (GC) and decreased numbers of immature B cells; the genes targeted by OcaB were not determined. Here we report that OcaB is essential for V(D)J recombination of a subset of Igkappa genes. We show that OcaB modulates recombination by directly enhancing Igkappa gene transcription in vivo. |
