| First Author | Zepp JA | Year | 2017 |
| Journal | J Immunol | Volume | 199 |
| Issue | 11 | Pages | 3849-3857 |
| PubMed ID | 29070673 | Mgi Jnum | J:251136 |
| Mgi Id | MGI:6104685 | Doi | 10.4049/jimmunol.1601540 |
| Citation | Zepp JA, et al. (2017) IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis. J Immunol 199(11):3849-3857 |
| abstractText | This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of IL-17A signaling in mice attenuated tissue repair of dextran sulfate sodium (DSS)-induced damage in colon epithelium and markedly reduced tumor development in an azoxymethane/DSS model of colitis-associated cancer. A novel IL-17A target gene, PLET1 (a progenitor cell marker involved in wound healing), was highly induced in DSS-treated colon tissues and tumors in an IL-17RC-dependent manner. PLET1 expression was induced in LGR5(+) colon epithelial cells after DSS treatment. LGR5(+)PLET1(+) marks a highly proliferative cell population with enhanced expression of IL-17A target genes. PLET1 deficiency impaired tissue repair of DSS-induced damage in colon epithelium and reduced tumor formation in an azoxymethane/DSS model of colitis-associated cancer. Our results suggest that IL-17A-induced PLET1 expression contributes to tissue repair and colon tumorigenesis. |
