| First Author | Hedtjärn M | Year | 2005 |
| Journal | Neurosci Lett | Volume | 373 |
| Issue | 1 | Pages | 16-20 |
| PubMed ID | 15555769 | Mgi Jnum | J:104826 |
| Mgi Id | MGI:3612829 | Doi | 10.1016/j.neulet.2004.09.062 |
| Citation | Hedtjarn M, et al. (2005) White matter injury in the immature brain: role of interleukin-18. Neurosci Lett 373(1):16-20 |
| abstractText | Inflammation is likely to be important in the pathophysiology of white matter damage in the immature brain. In order to investigate the involvement of interleukin (IL)-18, we subjected 9-day-old IL-18-deficient and wild-type (WT) mice to hypoxia-ischemia (HI) (unilateral carotid ligation and exposure to 10% oxygen) and white matter injury was evaluated after 3 days by immunostaining for myelin basic protein (MBP) and neurofilament (NF). The immunoreactivity of MBP was significantly higher by 92, 49 and 21%, respectively, in subcortical white matter, striatum and thalamus in IL-18-deficient mice versus WT mice following HI. Similarly, there was a more pronounced immunoreactivity of NF by 78% in the subcortical white matter in IL-18 KO versus WT mice. IL-18 was expressed by astrocytes and microglia, whereas the IL-18 receptor was mainly found in astrocytes localized in and around the subventricular white matter. Taken together, these results indicate that release of IL-18 may play an important role in the development of white matter injury in the neonatal brain. |
