| First Author | Sousa LM | Year | 2015 |
| Journal | Cytokine | Volume | 74 |
| Issue | 2 | Pages | 327-30 |
| PubMed ID | 26009021 | Mgi Jnum | J:329084 |
| Mgi Id | MGI:6880404 | Doi | 10.1016/j.cyto.2015.01.021 |
| Citation | Sousa LM, et al. (2015) IL-18 contributes to susceptibility to Leishmania amazonensis infection by macrophage-independent mechanisms. Cytokine 74(2):327-30 |
| abstractText | We evaluated the role of IL-18 during Leishmania amazonensis infection in C57BL/6 mice, using IL-18KO mice. We showed that IL-18 is involved in susceptibility to L. amazonensis, since IL-18KO mice presented reduced lesions and parasite loads. Because macrophages are the host cells of the parasite, we investigated if macrophages were involved in IL-18-mediated susceptibility to L. amazonensis. We showed that macrophages obtained from WT or IL-18KO responded similarly to L. amazonensis infection. Moreover, we showed that C57BL/6 macrophages do not respond to IL-18, since they do not express IL-18R. Therefore, macrophages are not involved in IL-18-mediated susceptibility to L. amazonensis. |
