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Allele : App<tm1Dbo> amyloid beta precursor protein; targeted mutation 1, David R Borchelt

Primary Identifier	MGI:2136847	Allele Type	Targeted
Attribute String	Null/knockout	Gene	App
Transmission	Germline	Strain of Origin	129S7/SvEvBrd-Hprt1<b-m2>
Is Recombinase	false	Is Wild Type	false

molecularNote

A neomycin resistance cassette replaced a 3.8 kb sequence including the promoter region and first exon. Northern blot analysis did not detect mRNA in brain or kidney of homozygous mutant mice.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
App-,
App-

earliestPublication:
Zheng H, et al. (1995) beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81(4):525-31

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

5 Carried By

0 Driven By

122 Publication categories

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