| First Author | Pramatarova A | Year | 2008 |
| Journal | Mol Cell Neurosci | Volume | 37 |
| Issue | 1 | Pages | 178-86 |
| PubMed ID | 18029196 | Mgi Jnum | J:132599 |
| Mgi Id | MGI:3776345 | Doi | 10.1016/j.mcn.2007.09.008 |
| Citation | Pramatarova A, et al. (2008) A genetic interaction between the APP and Dab1 genes influences brain development. Mol Cell Neurosci 37(1):178-86 |
| abstractText | The Dab1 docking protein is required for the proper organization of brain laminae and for a signal transduction pathway initiated by Reelin binding to the ApoER2 and VLDLR receptors on the cell surface of neurons. Dab1 physically interacts with APP; however, it is not known whether the APP gene influences Dab1 function. Here we demonstrate a genetic interaction between Dab1 and APP. Dab1-hypomorphic animals have neuronal ectopias in the neocortex and reduced cerebellar volume, possibly a consequence of Purkinje cell misplacement. These phenotypes are exacerbated in transgenic animals overexpressing a mutant form of APP, APP(swe), which is characterized by increased processing at the beta-secretase site. The Dab1-hypomorphic phenotype is improved in the cerebellum of animals that are deficient for APP. Together this suggests that APP expression constrains the consequences of Dab1 activity during brain development. |
