| First Author | Meijer MT | Year | 2021 |
| Journal | Front Immunol | Volume | 12 |
| Pages | 600979 | PubMed ID | 33776992 |
| Mgi Jnum | J:328881 | Mgi Id | MGI:6808111 |
| Doi | 10.3389/fimmu.2021.600979 | Citation | Meijer MT, et al. (2021) Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice. Front Immunol 12:600979 |
| abstractText | Tenascin C (TNC) is an extracellular matrix glycoprotein that recently emerged as an immunomodulator. TNC-deficient (TNC(-/-)) mice were reported to have a reduced inflammatory response upon systemic administration of lipopolysaccharide, the toxic component of gram-negative bacteria. Here, we investigated the role of TNC during gram-negative pneumonia derived sepsis. TNC(+/+) and TNC(-/-) mice were infected with Klebsiella pneumoniae via the airways and sacrificed 24 and 42 h thereafter for further analysis. Pulmonary TNC protein levels were elevated 42 h after infection in TNC(+/+) mice and remained undetectable in TNC(-/-) mice. TNC(-/-) mice showed modestly lower bacterial loads in lungs and blood, and a somewhat reduced local-but not systemic-inflammatory response. Moreover, TNC(-/-) and TNC(+/+) mice did not differ with regard to neutrophil recruitment, lung pathology or plasma markers of distal organ injury. These results suggest that while TNC shapes the immune response during lipopolysaccharide-induced inflammation, this role may be superseded during pneumosepsis caused by a common gram-negative pathogen. |
