| First Author | Diala I | Year | 2013 |
| Journal | EMBO Rep | Volume | 14 |
| Issue | 4 | Pages | 356-63 |
| PubMed ID | 23429341 | Mgi Jnum | J:197196 |
| Mgi Id | MGI:5491105 | Doi | 10.1038/embor.2013.16 |
| Citation | Diala I, et al. (2013) Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway. EMBO Rep 14(4):356-63 |
| abstractText | The DNA-binding protein TRF2 is essential for telomere protection and chromosome stability in mammals. We show here that TRF2 expression is activated by the Wnt/beta-catenin signalling pathway in human cancer and normal cells as well as in mouse intestinal tissues. Furthermore, beta-catenin binds to TRF2 gene regulatory regions that are functional in a luciferase transactivating assay. Reduced beta-catenin expression in cancer cells triggers a marked increase in telomere dysfunction, which can be reversed by TRF2 overexpression. We conclude that the Wnt/beta-catenin signalling pathway maintains a level of TRF2 critical for telomere protection. This is expected to have an important role during development, adult stem cell function and oncogenesis. |
