| First Author | Macdougall CE | Year | 2018 |
| Journal | Cell Metab | Volume | 27 |
| Issue | 3 | Pages | 588-601.e4 |
| PubMed ID | 29514067 | Mgi Jnum | J:260500 |
| Mgi Id | MGI:6150206 | Doi | 10.1016/j.cmet.2018.02.007 |
| Citation | Macdougall CE, et al. (2018) Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metab 27(3):588-601.e4 |
| abstractText | Visceral adipose tissue (VAT) has multiple roles in orchestrating whole-body energy homeostasis. In addition, VAT is now considered an immune site harboring an array of innate and adaptive immune cells with a direct role in immune surveillance and host defense. We report that conventional dendritic cells (cDCs) in VAT acquire a tolerogenic phenotype through upregulation of pathways involved in adipocyte differentiation. While activation of the Wnt/beta-catenin pathway in cDC1 DCs induces IL-10 production, upregulation of the PPARgamma pathway in cDC2 DCs directly suppresses their activation. Combined, they promote an anti-inflammatory milieu in vivo delaying the onset of obesity-induced chronic inflammation and insulin resistance. Under long-term over-nutrition, changes in adipocyte biology curtail beta-catenin and PPARgamma activation, contributing to VAT inflammation. |
