| First Author | Somaiya RD | Year | 2022 |
| Journal | Elife | Volume | 11 |
| PubMed ID | 36342840 | Mgi Jnum | J:330720 |
| Mgi Id | MGI:7384076 | Doi | 10.7554/eLife.79833 |
| Citation | Somaiya RD, et al. (2022) Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus. Elife 11:e79833 |
| abstractText | Axons of retinal ganglion cells (RGCs) play critical roles in the development of inhibitory circuits in visual thalamus. We previously reported that RGC axons signal astrocytes to induce the expression of fibroblast growth factor 15 (FGF15), a motogen required for GABAergic interneuron migration into visual thalamus. However, how retinal axons induce thalamic astrocytes to generate <i>Fgf15</i> and influence interneuron migration remains unknown. Here, we demonstrate that impairing RGC activity had little impact on interneuron recruitment into mouse visual thalamus. Instead, our data show that retinal-derived sonic hedgehog (SHH) is essential for interneuron recruitment. Specifically, we show that thalamus-projecting RGCs express SHH and thalamic astrocytes generate downstream components of SHH signaling. Deletion of RGC-derived SHH leads to a significant decrease in <i>Fgf15</i> expression, as well as in the percentage of interneurons recruited into visual thalamus. Overall, our findings identify a morphogen-dependent neuron-astrocyte signaling mechanism essential for the migration of thalamic interneurons. |
