| First Author | Bluske KK | Year | 2009 |
| Journal | Dev Dyn | Volume | 238 |
| Issue | 12 | Pages | 3297-309 |
| PubMed ID | 19924825 | Mgi Jnum | J:154363 |
| Mgi Id | MGI:4367914 | Doi | 10.1002/dvdy.22167 |
| Citation | Bluske KK, et al. (2009) Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus. Dev Dyn 238(12):3297-3309 |
| abstractText | In neural development, several Wnt genes are expressed in the vertebrate diencephalon, including the thalamus. However, roles of Wnt signaling in the thalamus during neurogenesis are not well understood. We examined Wnt/beta-catenin activity in embryonic mouse thalamus and found that a Wnt target gene Axin2 and reporter activity of BAT-gal transgenic mice show similar, differential patterns within the thalamic ventricular zone, where ventral and rostral regions had lower activity than other regions. Expression of Wnt ligands and signaling components also showed complex, differential patterns. Finally, based on partially reciprocal patterns of Wnt and Shh signals in the thalamic ventricular zone, we tested if Shh signal is sufficient or necessary for the differential Axin2 expression. Analysis of mice with enhanced or reduced Shh signal showed that Axin2 expression is similar to controls. These results suggest that differential Wnt signaling may play a role in patterning the thalamus independent of Shh signaling. Developmental Dynamics 238:3297-3309, 2009. (c) 2009 Wiley-Liss, Inc. |
