| First Author | Weng SY | Year | 2018 |
| Journal | EBioMedicine | Volume | 29 |
| Pages | 92-103 | PubMed ID | 29463471 |
| Mgi Jnum | J:278216 | Mgi Id | MGI:6296138 |
| Doi | 10.1016/j.ebiom.2018.01.028 | Citation | Weng SY, et al. (2018) IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal. EBioMedicine 29:92-103 |
| abstractText | Chronic hepatitis leads to liver fibrosis and cirrhosis. Cirrhosis is a major cause of worldwide morbidity and mortality. Macrophages play a key role in fibrosis progression and reversal. However, the signals that determine fibrogenic vs fibrolytic macrophage function remain ill defined. We studied the role of interleukin-4 receptor alpha (IL-4Ralpha), a potential central switch of macrophage polarization, in liver fibrosis progression and reversal. We demonstrate that inflammatory monocyte infiltration and liver fibrogenesis were suppressed in general IL-4Ralpha(-/-) as well as in macrophage-specific IL-4Ralpha(-/-) (IL-4Ralpha(DeltaLysM)) mice. However, with deletion of IL-4Ralpha(DeltaLysM) spontaneous fibrosis reversal was retarded. Results were replicated by pharmacological intervention using IL-4Ralpha-specific antisense oligonucleotides. Retarded resolution was linked to the loss of M2-type resident macrophages, which secreted MMP-12 through IL-4 and IL-13-mediated phospho-STAT6 activation. We conclude that IL-4Ralpha signaling regulates macrophage functional polarization in a context-dependent manner. Pharmacological targeting of macrophage polarization therefore requires disease stage-specific treatment strategies. RESEARCH IN CONTEXT: Alternative (M2-type) macrophage activation through IL-4Ralpha promotes liver inflammation and fibrosis progression but speeds up fibrosis reversal. This demonstrates context dependent, opposing roles of M2-type macrophages. During reversal IL-4Ralpha induces fibrolytic MMPs, especially MMP-12, through STAT6. Liver-specific antisense oligonucleotides efficiently block IL-4Ralpha expression and attenuate fibrosis progression. |
