| First Author | Jing Y | Year | 2021 |
| Journal | Front Immunol | Volume | 12 |
| Pages | 651860 | PubMed ID | 34381443 |
| Mgi Jnum | J:359758 | Mgi Id | MGI:6817632 |
| Doi | 10.3389/fimmu.2021.651860 | Citation | Jing Y, et al. (2021) cDC1 Dependent Accumulation of Memory T Cells Is Required for Chronic Autoimmune Inflammation in Murine Testis. Front Immunol 12:651860 |
| abstractText | As an immune privilege site, there are various types of immune cells in the testis. Previous research has been focused on the testicular macrophages, and much less is known about the T cells in the testis. Here, we found that T cells with memory phenotypes were the most abundant leukocyte in the testis except for macrophages. Our results showed that the proportion of testicular T cells increases gradually from birth to adulthood in mice and that the primary type of T cells changed from gammadeltaTCR(+) T cells to alphabetaTCR(+) T cells. In addition, under homeostatic conditions, CD8(+) T cells are the dominant subgroup and have different phenotypic characteristics from CD4(+) T cells. We found that cDC1, but not cDC2, is necessary for the presence of T cells in the testis under physiological state. A significant decrease of T cells does not have a deleterious effect on the development of the testis or spermatogenesis. However, cDC1-dependent T cells play an indispensable role in chronic autoimmune orchitis of the testis. Collectively, our multifaceted data provide a comprehensive picture of the accumulation, localization, and function of testicular T cells. |
