| First Author | Vielnascher RM | Year | 2014 |
| Journal | Transgenic Res | Volume | 23 |
| Issue | 3 | Pages | 519-29 |
| PubMed ID | 24696087 | Mgi Jnum | J:215350 |
| Mgi Id | MGI:5605144 | Doi | 10.1007/s11248-014-9795-y |
| Citation | Vielnascher RM, et al. (2014) Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance. Transgenic Res 23(3):519-29 |
| abstractText | Tyrosine kinase 2 (TYK2) has a pivotal role in immunity to infection and tumor surveillance. It is associated with several cytokine receptor chains including type I interferon (IFN) receptor 1 (IFNAR1), interleukin- (IL-) 12 receptor beta 1 (IL-12Rb1) and IL-10R2. We have generated a mouse with a conditional Tyk2 null allele and proved integrity of the conditional Tyk2 locus. TYK2 was successfully removed by the use of ubiquitous and tissue-specific Cre-expressing mouse strains. Myeloid TYK2 was found to critically contribute to the defense against murine cytomegalovirus. Ubiquitous TYK2 ablation severely impaired tumor immunosurveillance, while deletion in myeloid, dendritic or T cells alone showed no effect. The conditional Tyk2 mouse strain will be instrumental to further dissect TYK2 functions in infection, inflammation and cancer. |
