| First Author | Reboll MR | Year | 2022 |
| Journal | Science | Volume | 376 |
| Issue | 6599 | Pages | 1343-1347 |
| PubMed ID | 35709278 | Mgi Jnum | J:326442 |
| Mgi Id | MGI:7310494 | Doi | 10.1126/science.abn3027 |
| Citation | Reboll MR, et al. (2022) Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase. Science 376(6599):1343-1347 |
| abstractText | Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell-endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver of postinfarction angiogenesis and high-affinity ligand for the stem cell factor receptor KIT (KIT receptor tyrosine kinase). METRNL mediated angiogenic effects in cultured human endothelial cells through KIT-dependent signaling pathways. In a mouse model of myocardial infarction, METRNL promoted infarct repair by selectively expanding the KIT-expressing endothelial cell population in the infarct border zone. Metrnl-deficient mice failed to mount this KIT-dependent angiogenic response and developed severe postinfarction heart failure. Our data establish METRNL as a KIT receptor ligand in the context of ischemic tissue repair. |
