| First Author | Li C | Year | 2018 |
| Journal | Sci Rep | Volume | 8 |
| Issue | 1 | Pages | 3603 |
| PubMed ID | 29483608 | Mgi Jnum | J:292909 |
| Mgi Id | MGI:6163052 | Doi | 10.1038/s41598-018-22039-9 |
| Citation | Li C, et al. (2018) HIF1alpha-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection. Sci Rep 8(1):3603 |
| abstractText | Macrophages are important innate immune defense system cells in the fight against bacterial and fungal pathogenic infections. They exhibit significant plasticity, particularly with their ability to undergo functional differentiation. Additionally, HIF1alpha is critically involved in the functional differentiation of macrophages during inflammation. However, the role of macrophage HIF1alpha in protecting against different pathogenic infections remains unclear. In this study, we investigated and compared the roles of HIF1alpha in different macrophage functional effects of bacterial and fungal infections in vitro and in vivo. We found that bacterial and fungal infections produced similar effects on macrophage functional differentiation. HIF1alpha deficiency inhibited pro-inflammatory macrophage functional activities when cells were stimulated with LPS or curdlan in vitro or when mice were infected with L. monocytogenes or C. albicans in vivo, thus decreasing pro-inflammatory TNFalpha and IL-6 secretion associated with pathogenic microorganism survival. Alteration of glycolytic pathway activation was required for the functional differentiation of pro-inflammatory macrophages in protecting against bacterial and fungal infections. Thus, the HIF1alpha-dependent glycolytic pathway is essential for pro-inflammatory macrophage functional differentiation in protecting against bacterial and fungal infections. |
