| First Author | Malo CS | Year | 2018 |
| Journal | Nat Commun | Volume | 9 |
| Issue | 1 | Pages | 633 |
| PubMed ID | 29434238 | Mgi Jnum | J:314188 |
| Mgi Id | MGI:6118998 | Doi | 10.1038/s41467-018-03037-x |
| Citation | Malo CS, et al. (2018) Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 (+) T cell responses. Nat Commun 9(1):633 |
| abstractText | The contribution of antigen-presenting cell (APC) types in generating CD8(+) T cell responses in the central nervous system (CNS) is not fully defined, limiting the development of vaccines and understanding of immune-mediated neuropathology. Here, we generate a transgenic mouse that enables cell-specific deletion of the H-2Kb MHC class I molecule. By deleting H-2K(b) on dendritic cells and macrophages, we compare the effect of each APC in three distinct models of neuroinflammation: picornavirus infection, experimental cerebral malaria, and a syngeneic glioma. Dendritic cells and macrophages both activate CD8(+) T cell responses in response to these CNS immunological challenges. However, the extent to which each of these APCs contributes to CD8(+) T cell priming varies. These findings reveal distinct functions for dendritic cells and macrophages in generating CD8(+) T cell responses to neurological disease. |
