| First Author | Tsumura H | Year | 2012 |
| Journal | Cell Immunol | Volume | 276 |
| Issue | 1-2 | Pages | 128-34 |
| PubMed ID | 22624878 | Mgi Jnum | J:188365 |
| Mgi Id | MGI:5440376 | Doi | 10.1016/j.cellimm.2012.04.012 |
| Citation | Tsumura H, et al. (2012) The role of CD98hc in mouse macrophage functions. Cell Immunol 276(1-2):128-34 |
| abstractText | CD98hc is a type II transmembrane protein that covalently links to one of several L-type amino acid transporters. CD98hc was first identified as a lymphocyte activation marker. In this study, we examined the role that CD98hc plays in the functions of macrophages using tissue specific knock-out miceCD98hc (CD98hc(flox/-)LysM-cre mice). When isolated peritoneal macrophages were incubated for 48 h, the macrophages obtained from the knock-out mice showed round-shaped morphologies, while almost all of the cells obtained from the control mice were spindle-shaped. The macrophage functions such as the antigen-presenting, phagocytic, and fusion activities, have been reported to decrease in CD98hc-deficient peritoneal macrophages. In addition, when the CD98hc deficient macrophages were stimulated with either IFN-gamma/LPS or IL-4, the production of NO(2) or arginase-I decreased in comparison to that observed in the control macrophages. These findings show that the CD98hc molecules play an important role in the activation and functions of macrophages. |
