| First Author | Bryson KJ | Year | 2011 |
| Journal | PLoS Negl Trop Dis | Volume | 5 |
| Issue | 1 | Pages | e930 |
| PubMed ID | 21245915 | Mgi Jnum | J:168069 |
| Mgi Id | MGI:4881845 | Doi | 10.1371/journal.pntd.0000930 |
| Citation | Bryson KJ, et al. (2011) BALB/c Mice Deficient in CD4 T Cell IL-4Ralpha Expression Control Leishmania mexicana Load although Female but Not Male Mice Develop a Healer Phenotype. PLoS Negl Trop Dis 5(1):e930 |
| abstractText | Immunologically intact BALB/c mice infected with Leishmania mexicana develop non-healing progressively growing lesions associated with a biased Th2 response while similarly infected IL-4Ralpha-deficient mice fail to develop lesions and develop a robust Th1 response. In order to determine the functional target(s) for IL-4/IL-13 inducing non-healing disease, the course of L. mexicana infection was monitored in mice lacking IL-4Ralpha expression in specific cellular compartments. A deficiency of IL-4Ralpha expression on macrophages/neutrophils (in LysM(cre)IL-4Ralpha(-/lox) animals) had minimal effect on the outcome of L. mexicana infection compared with control (IL-4Ralpha(-/flox)) mice. In contrast, CD4(+) T cell specific (Lck(cre)IL-4Ralpha(-/lox)) IL-4Ralpha(-/-) mice infected with L. mexicana developed small lesions, which subsequently healed in female mice, but persisted in adult male mice. While a strong Th1 response was manifest in both male and female CD4(+) T cell specific IL-4Ralpha(-/-) mice infected with L. mexicana, induction of IL-4 was manifest in males but not females, independently of CD4(+) T cell IL-4 responsiveness. Similar results were obtained using pan-T cell specific (iLck(cre)IL-4Ralpha(-/lox)) IL-4Ralpha(-/-) mice. Collectively these data demonstrate that upon infection with L. mexicana, initial lesion growth in BALB/c mice is dependent on non-T cell population(s) responsive to IL-4/IL-13 while progressive infection is dependent on CD4(+) T cells responsive to IL-4. |
