| First Author | Orthgiess J | Year | 2016 |
| Journal | Eur J Immunol | Volume | 46 |
| Issue | 6 | Pages | 1529-32 |
| PubMed ID | 27062494 | Mgi Jnum | J:243186 |
| Mgi Id | MGI:5907895 | Doi | 10.1002/eji.201546108 |
| Citation | Orthgiess J, et al. (2016) Neurons exhibit Lyz2 promoter activity in vivo: Implications for using LysM-Cre mice in myeloid cell research. Eur J Immunol 46(6):1529-32 |
| abstractText | To characterize LysM-Cre mediated gene targeting in mice, we crossed LysM-Cre mice to two independent reporter-mouse lines (tdTomato or YFP). Surprisingly, we found that more than 90% of cells with LysM-Cre mediated recombination in the brain were neurons, rather than myeloid cells, such as microglia. Hence, by using the LysM-Cre mouse line for conditional knockout approaches, a significant neuronal recombination needs to be considered. |
