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Allele : Sdc1<tm1Cma> syndecan 1; targeted mutation 1, Caroline M Alexander

Primary Identifier	MGI:1934652	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Sdc1
Transmission	Germline	Strain of Origin	129S4/SvJae
Is Recombinase	false	Is Wild Type	false

molecularNote

Insertion of a PGK-neomycin resistance cassette into the signal sequence in exon 1 disrupted the gene. Immunostaining of myoepithelial cells did not detect protein in homozygous mice.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
synd-1-,
Sdc1-,
synd-1-,
Sdc1<tm1Step>,
Synd1ko,
Sdc1-,
Sdc1<tm1Bfd>,
Sdc1<tm1Step>,
Synd1ko,
Sdc1<tm1Bfd>

earliestPublication:
Alexander CM, et al. (2000) Syndecan-1 is required for wnt-1-induced mammary tumorigenesis in mice. Nat Genet 25(3):329-32

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

76 Publication categories

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