| Primary Identifier | MGI:1934933 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Fcer2a |
| Transmission | Germline | Strain of Origin | 129S/SvEv-Gpi1<c> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A neomycin resistance cassette replaced 800 bp of the gene including part of exon 10, all of exon 11, and part of exon 12. The deleted sequences encode the carboxy-terminus, including the lectin homology domain with sequences that bind the C epsilon domain of IgE. Northern blot analysis of spleen did not detect transcript in homozygous mutant mice. Flow cytometric analysis did not detect protein on the surface of splenic B cells in homozygous mutant mice. Immunocytochemical analysis did not detect protein in asteroid dentritic cells near the corticomedullary junction of homozygous mutant thymus. |
