| First Author | Jun S | Year | 2023 |
| Journal | Dev Cell | Volume | 58 |
| Issue | 21 | Pages | 2195-2205.e5 |
| PubMed ID | 37647897 | Mgi Jnum | J:342314 |
| Mgi Id | MGI:7548245 | Doi | 10.1016/j.devcel.2023.08.003 |
| Citation | Jun S, et al. (2023) Control of murine brown adipocyte development by GATA6. Dev Cell 58(21):2195-2205.e5 |
| abstractText | Brown adipose tissue (BAT) is a thermogenic organ that protects animals against hypothermia and obesity. BAT derives from the multipotent paraxial mesoderm; however, the identity of embryonic brown fat progenitor cells and regulators of adipogenic commitment are unclear. Here, we performed single-cell gene expression analyses of mesenchymal cells during mouse embryogenesis with a focus on BAT development. We identified cell populations associated with the development of BAT, including Dpp4+ cells that emerge at the onset of adipogenic commitment. Immunostaining and lineage-tracing studies show that Dpp4+ cells constitute the BAT fascia and contribute minorly as adipocyte progenitors. Additionally, we identified the transcription factor GATA6 as a marker of brown adipogenic progenitor cells. Deletion of Gata6 in the brown fat lineage resulted in a striking loss of BAT. Together, these results identify progenitor and transitional cells in the brown adipose lineage and define a crucial role for GATA6 in BAT development. |
