| First Author | Lissner MM | Year | 2020 |
| Journal | Elife | Volume | 9 |
| PubMed ID | 33021470 | Mgi Jnum | J:298692 |
| Mgi Id | MGI:6477126 | Doi | 10.7554/eLife.60165 |
| Citation | Lissner MM, et al. (2020) Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury. Elife 9:e60165 |
| abstractText | Systemic metabolic reprogramming induced by infection exerts profound, pathogen-specific effects on infection outcome. Here, we detail the host immune and metabolic response during sickness and recovery in a mouse model of malaria. We describe extensive alterations in metabolism during acute infection, and identify increases in host-derived metabolites that signal through the aryl hydrocarbon receptor (AHR), a transcription factor with immunomodulatory functions. We find that Ahr(-/-) mice are more susceptible to malaria and develop high plasma heme and acute kidney injury. This phenotype is dependent on AHR in Tek-expressing radioresistant cells. Our findings identify a role for AHR in limiting tissue damage during malaria. Furthermore, this work demonstrates the critical role of host metabolism in surviving infection. |
