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Allele : Ctsl<tm1Cptr> cathepsin L; targeted mutation 1, Christoph Peters

Primary Identifier  MGI:2136432 Allele Type  Targeted
Attribute String  Null/knockout Gene  Ctsl
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
description  In combination with Ctsbtm1Jde, double homozygous mutant have some similarities but distinct phenotypic characteristics compared to the human syndrome: Neuronal Ceroid Lipofuscinoses (NLCs)
molecularNote  Insertion of a neomycin resistance cassette into exon 3. Northern and Western analysis failed to detect any signal in homozygous mutant mice. No Ctsl enzymatic activity was detected using a synthetic substrate.
  • mutations:
  • Insertion
  • synonyms:
  • CL-,
  • L<->,
  • ctsl-,
  • ctsl-,
  • catL-,
  • catL-,
  • CL-,
  • L<->,
  • Cat L<->,
  • Cat L<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

79 Publication categories