| First Author | Niebert S | Year | 2017 |
| Journal | Front Mol Neurosci | Volume | 10 |
| Pages | 299 | PubMed ID | 28983239 |
| Mgi Jnum | J:321308 | Mgi Id | MGI:6818873 |
| Doi | 10.3389/fnmol.2017.00299 | Citation | Niebert S, et al. (2017) The Serotonin Receptor Subtype 5b Specifically Interacts with Serotonin Receptor Subtype 1A. Front Mol Neurosci 10:299 |
| abstractText | Previously, we described the dysregulation of serotonin (5-HT) receptor subtype 5b (5-ht5b) in a mouse model of Rett syndrome (RTT). 5-ht5b has not been extensively studied, so we set out to characterize it in more detail. Unlike common cell surface receptors, 5-ht5b displays no membrane expression, while receptor clusters are located in endosomes. This unusual subcellular localization is at least in part controlled by glycosylation of the N-terminus, with 5-ht5b possessing fewer glycosylation sites than related receptors. We analyzed whether the localization to endosomes has any functional relevance and found that 5-ht5b receptors can specifically interact with 5-HT1A receptors and retain them in endosomal compartments. This interaction reduces 5-HT1A surface expression and is mediated by interactions between the fourth and fifth trans-membrane domain (TMD). This possibly represents a mechanism by which 5-ht5b receptors regulate the activity of other 5-HT receptor. |
