| First Author | Loro E | Year | 2019 |
| Journal | Front Physiol | Volume | 10 |
| Pages | 1439 | PubMed ID | 31849697 |
| Mgi Jnum | J:290766 | Mgi Id | MGI:6442770 |
| Doi | 10.3389/fphys.2019.01439 | Citation | Loro E, et al. (2019) Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated by in vivo Isometric Muscle Contractions. Front Physiol 10:1439 |
| abstractText | Lack of interleukin 15 receptor alpha (IL15RA) increases spontaneous activity, exercise capacity and protects from diet-induced obesity by enhancing muscle energy metabolism, suggesting a role as exercise mimetic for IL15RA antagonists. Using controlled in vivo muscle stimulation mimicking moderate exercise in normal and Il15ra(-/-) mice, we mapped and contrasted the metabolic pathways activated upon stimulation or deletion of IL15RA. Stimulation caused the differential regulation of 123 out of the 321 detected metabolites (FDR </= 0.05 and fold change >/= +/-1.5). The main energy pathways activated were fatty acid oxidation, nucleotide metabolism, and anaplerotic reactions. Notably, resting Il15ra(-/-) muscles were primed in a semi-exercised state, characterized by higher pool sizes of fatty acids oxidized to support muscle activity. These studies identify the role of IL15RA in the system-wide metabolic response to exercise and should enable translational studies to harness the potential of IL15RA blockade as a novel exercise mimetic strategy. |
