| First Author | Ledderose J | Year | 2013 |
| Journal | Sci Rep | Volume | 3 |
| Pages | 1514 | PubMed ID | 23515096 |
| Mgi Jnum | J:195283 | Mgi Id | MGI:5477853 |
| Doi | 10.1038/srep01514 | Citation | Ledderose J, et al. (2013) Maturation of postnatally generated olfactory bulb granule cells depends on functional gamma-protocadherin expression. Sci Rep 3:1514 |
| abstractText | gamma-protocadherins (gamma-pcdhs) are transmembrane receptor proteins ubiquitously expressed in the postnatal and adult mouse brain. gamma-pcdhs are required for normal neuronal development as shown for spinal cord interneurons, retinal ganglion cells and cortical neurons. To test the role of gamma-pcdhs during development of subventricular zone progenitor cells and their subsequent differentiation into olfactory granule cells we generated a conditional gamma-pcdh(lox/lox) allele (gamma-pcdh(lox/lox)) allowing for functional gamma-pcdh inactivation upon lentivirus-mediated Cre-recombinase expression selectively in subventricular zone progenitor cells. While gamma-pcdh loss did not alter the proliferation of subventricular zone progenitors, gamma-pcdh ko progenitors that reached the main olfactory bulb showed a significant reduction in dendritic arborization and failed to develop dendritic spines. Our results suggest that olfactory bulb granule cell maturation necessitates functional gamma-pcdh expression. |
