| First Author | Koizumi H | Year | 2006 |
| Journal | Neuron | Volume | 49 |
| Issue | 1 | Pages | 55-66 |
| PubMed ID | 16387639 | Mgi Jnum | J:105300 |
| Mgi Id | MGI:3614627 | Doi | 10.1016/j.neuron.2005.10.040 |
| Citation | Koizumi H, et al. (2006) Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. Neuron 49(1):55-66 |
| abstractText | The potential role of doublecortin (Dcx), encoding a microtubule-associated protein, in brain development has remained controversial. Humans with mutations show profound alterations in cortical lamination, whereas in mouse, RNAi-mediated knockdown but not germline knockout shows abnormal positioning of cortical neurons. Here, we report that the doublecortin-like kinase (Dclk) gene functions in a partially redundant pathway with Dcx in the formation of axonal projections across the midline and migration of cortical neurons. Dosage-dependent genetic effects were observed in both interhemispheric connectivity and migration of cortically and subcortically derived neurons. Surprisingly, RNAi-mediated knockdown of either gene results in similar migration defects. These results indicate the Dcx microtubule-associated protein family is required for proper neuronal migration and axonal wiring. |
