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Publication : Mice carrying a CAR-2 null allele lack carbonic anhydrase II immunohistochemically and show vascular calcification.

First Author  Spicer SS Year  1989
Journal  Am J Pathol Volume  134
Issue  4 Pages  947-54
PubMed ID  2495727 Mgi Jnum  J:289498
Mgi Id  MGI:6437023 Citation  Spicer SS, et al. (1989) Mice carrying a CAR-2 null allele lack carbonic anhydrase II immunohistochemically and show vascular calcification. Am J Pathol 134(4):947-54
abstractText  Mutant mice reported to lack carbonic anhydrase isoenzyme II (CA II) have been examined here for immunocytochemical evidence of CA II and for histopathologic change. All histologic sites that immunostain for CA II in a wide range of organs in normal mice failed to show such immunoreactivity in the homozygous mutants. The CA II-deficient mice differed from controls in evidencing an age dependent medial calcification of small arteries in a number of organs. The male genital tract revealed the most extensive arterial calcinosis and males were possibly more affected in general than females. One or another Car-2n/Car-2n mouse showed changes additionally in uterus, small bowel, lymph nodes, or renal pelvis.
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