| First Author | King TE | Year | 2003 |
| Journal | Neuroreport | Volume | 14 |
| Issue | 12 | Pages | 1603-7 |
| PubMed ID | 14502084 | Mgi Jnum | J:103651 |
| Mgi Id | MGI:3610580 | Doi | 10.1097/00001756-200308260-00012 |
| Citation | King TE, et al. (2003) Functional development of neurokinin peptides substance P and neurokinin A in nociception. Neuroreport 14(12):1603-7 |
| abstractText | It is unclear how neonates respond to noxious stimuli. This study examined the role of neurokinin peptides in 3- and 21-day-old rat pups using the preprotachykinin-A (PPTA) knockout mouse, lacking neurokinin A and substance P. We assessed pain behaviors of these mice before the neurokinin system is putatively active, 3 days after birth, and after this system is active, 21 days after birth. The lack of these peptides failed to alter behavioral responses to nociceptive stimulation in the 3-day-old mice. The 21-day-old mice lacking these peptides were less responsive to 5 microl 2% formalin and to high intensity thermal and mechanical stimuli. Thus, the neurokinins appear not to be an important mechanism in the processing of nociceptive information in the infant. |
