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Allele : Ret<tm1Cos> ret proto-oncogene; targeted mutation 1, Frank Costantini

Primary Identifier  MGI:2136894 Allele Type  Targeted
Attribute String  Null/knockout Gene  Ret
Transmission  Germline Strain of Origin  129S/SvEv-Gpi1<c>
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin resistance cassette replaced 0.8 kb of sequence, including the codon for an invariant lysine required for kinase activity. Northern blot analysis did not detect normal transcripts in brains of homozygous mice, but did detect several transcripts with sizes consistent with predicted products of the mutant allele.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • c-ret-,
  • Ret-,
  • Ret-,
  • ret-k-,
  • ret-k-,
  • c-ret-
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

61 Publication categories