| First Author | Eriksson M | Year | 2010 |
| Journal | Neurosci Lett | Volume | 475 |
| Issue | 1 | Pages | 33-7 |
| PubMed ID | 20304030 | Mgi Jnum | J:159901 |
| Mgi Id | MGI:4453048 | Doi | 10.1016/j.neulet.2010.03.039 |
| Citation | Eriksson M, et al. (2010) MAP1B binds to the NMDA receptor subunit NR3A and affects NR3A protein concentrations. Neurosci Lett 475(1):33-7 |
| abstractText | Incorporation of the N-methyl-d-aspartate receptor (NMDAR) subunit NR3A into functional NMDARs results in reduced channel conductance and Ca(2+) permeability. To further investigate the function of NR3A, we have set out to characterize its intracellular binding partners. Here, we report a novel protein interaction between NR3A and microtubule associated-protein (MAP) 1B, which both are localized to dendritic shafts and filopodia. NR3A protein levels were increased in MAP1B deficient (-/-) mice, with a corresponding decrease in NR1 levels, but the fraction of filopodia immunoreactive for NR3A was equal in cells from -/- and wild type (WT) mice. NR3A has previously been shown to interact with another member of the MAP1 family, MAP1S. We showed that MAP1S binds to microtubules in a similar manner as MAP1B, and suggest that MAP1S and MAP1B both are involved in regulating trafficking of NR3A-containing NMDAR. |
