| First Author | Salmon AM | Year | 1999 |
| Journal | Neuroreport | Volume | 10 |
| Issue | 4 | Pages | 849-54 |
| PubMed ID | 10208559 | Mgi Jnum | J:54422 |
| Mgi Id | MGI:1335275 | Doi | 10.1097/00001756-199903170-00033 |
| Citation | Salmon AM, et al. (1999) Modulation of morphine analgesia in alphaCGRP mutant mice. Neuroreport 10(4):849-54 |
| abstractText | A homozygous CGRP-/- mouse line was generated by the targeted disruption of exon 5 in the calcitonin/ alpha CGRP gene using homologous recombination. The mutant mice lack alpha CGRP mRNA. Furthermore CGRP immunoreactivity almost completely disappears from the spinal cord and is not at all observed in spinal ganglia and muscle synapses. However, motor end plates mere still detected by acetylcholinesterase staining. Antinociceptive behavior tested by the tail flick and hot plate tests did not significantly differ in mutant and mild-type mice, except when challenged by morphine. Paradoxically, morphine analgesia was reduced in mutant mice compared with controls in the tail flick test, but not in the hot plate test. Thus, alpha CGRP differentially modulates opiate pain pathways. NeuroReport 10:849-854 (C) 1999 Lippincott Williams & Wilkins. |
