| First Author | Zeng J | Year | 2018 |
| Journal | J Immunol | Volume | 200 |
| Issue | 10 | Pages | 3407-3419 |
| PubMed ID | 29626089 | Mgi Jnum | J:261496 |
| Mgi Id | MGI:6155386 | Doi | 10.4049/jimmunol.1701416 |
| Citation | Zeng J, et al. (2018) Stearic Acid Induces CD11c Expression in Proinflammatory Macrophages via Epidermal Fatty Acid Binding Protein. J Immunol 200(10):3407-3419 |
| abstractText | Obesity is associated with elevated levels of free fatty acids (FAs) and proinflammatory CD11c(+) macrophages. However, whether and how free FAs contribute to CD11c(+) macrophage differentiation and proinflammatory functions remain unclear. Here we report that dietary saturated FAs, but not unsaturated FAs, promoted the differentiation and function of CD11c(+) macrophages. Specifically, we demonstrated that stearic acid (SA) significantly induced CD11c expression in monocytes through activation of the nuclear retinoid acid receptor. More importantly, cytosolic expression of epidermal FA binding protein (E-FABP) in monocytes/macrophages was shown to be critical to the mediation of the SA-induced effect. Depletion of E-FABP not only inhibited SA-induced CD11c upregulation in macrophages in vitro but also abrogated high-saturated-fat diet-induced skin lesions in obese mouse models in vivo. Altogether, our data demonstrate a novel mechanism by which saturated FAs promote obesity-associated inflammation through inducing E-FABP/retinoid acid receptor-mediated differentiation of CD11c(+) macrophages. |
