| First Author | Hao J | Year | 2018 |
| Journal | Cancer Res | Volume | 78 |
| Issue | 9 | Pages | 2343-2355 |
| PubMed ID | 29437708 | Mgi Jnum | J:261890 |
| Mgi Id | MGI:6155894 | Doi | 10.1158/0008-5472.CAN-17-2465 |
| Citation | Hao J, et al. (2018) Expression of Adipocyte/Macrophage Fatty Acid-Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression. Cancer Res 78(9):2343-2355 |
| abstractText | Tumor-associated macrophages (TAM) play a critical role in cancer development and progression. However, the heterogeneity of TAM presents a major challenge to identify clinically relevant markers for protumor TAM. Here, we report that expression of adipocyte/macrophage fatty acid-binding protein (A-FABP) in TAM promotes breast cancer progression. Although upregulation of A-FABP was inversely associated with breast cancer survival, deficiency of A-FABP significantly reduced mammary tumor growth and metastasis. Furthermore, the protumor effect of A-FABP was mediated by TAM, in particular, in a subset of TAM with a CD11b(+)F4/80(+)MHCII(-)Ly6C(-) phenotype. A-FABP expression in TAM facilitated protumor IL6/STAT3 signaling through regulation of the NFkappaB/miR-29b pathway. Collectively, our results suggest A-FABP as a new functional marker for protumor TAM.Significance: These findings identify A-FABP as a functional marker for protumor macrophages, thus offering a new target for tumor immunotherapy. Cancer Res; 78(9); 2343-55. (c)2018 AACR. |
