| First Author | Jurek A | Year | 2016 |
| Journal | Exp Cell Res | Volume | 348 |
| Issue | 1 | Pages | 10-22 |
| PubMed ID | 27565439 | Mgi Jnum | J:235939 |
| Mgi Id | MGI:5804034 | Doi | 10.1016/j.yexcr.2016.08.017 |
| Citation | Jurek A, et al. (2016) Eph receptor interclass cooperation is required for the regulation of cell proliferation. Exp Cell Res 348(1):10-22 |
| abstractText | Cancer often arises by the constitutive activation of mitogenic pathways by mutations in stem cells. Eph receptors are unusual in that although they regulate the proliferation of stem/progenitor cells in many adult organs, they typically fail to transform cells. Multiple ephrins and Eph receptors are often co-expressed and are thought to be redundant, but we here describe an unexpected dichotomy with two homologous ligands, ephrin-B1 and ephrin-B2, regulating specifically migration or proliferation in the intestinal stem cell niche. We demonstrate that the combined activity of two different coexpressed Eph receptors of the A and B class assembled into common signaling clusters in response to ephrin-B2 is required for mitogenic signaling. The requirement of two different Eph receptors to convey mitogenic signals identifies a new type of cooperation within this receptor family and helps explain why constitutive activation of a single receptor fails to transform cells. |
