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Allele : Nos3<tm1Plh> nitric oxide synthase 3, endothelial cell; targeted mutation 1, Paul L Huang
Primary Identifier  MGI:2150145 Allele Type  Targeted
Attribute String  Null/knockout Gene  Nos3
Inheritance Mode  Dominant Transmission  Germline
Strain of Origin  129S4/SvJae Is Recombinase  false
Is Wild Type  false
molecularNote  A neomycin cassette replaced 3 exons that encode the NADPH ribose and adenine binding sites of the protein (amino acids 1010 - 1144). Western blots of protein extracts of brain, heart, lung, and aorta/vena cava from homozygous mutant mice showed no detectable encoded protein.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • NOSIII<->,
  • NOSIII<->,
  • eNOS KO,
  • eNOS<->,
  • eNOS<->,
  • eNOS KO
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

4 Carried By

0 Driven By

132 Publication categories





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