| First Author | Tanaka Y | Year | 2007 |
| Journal | Nat Immunol | Volume | 8 |
| Issue | 10 | Pages | 1067-75 |
| PubMed ID | 17767160 | Mgi Jnum | J:125275 |
| Mgi Id | MGI:3758117 | Doi | 10.1038/ni1506 |
| Citation | Tanaka Y, et al. (2007) T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-alpha subunit controlled by the Rac activator Dock2. Nat Immunol 8(10):1067-75 |
| abstractText | The lineage commitment of CD4(+) T cells is coordinately regulated by signals through the T cell receptor and cytokine receptors, yet how these signals are integrated remains elusive. Here we find that mice lacking Dock2, a Rac activator in lymphocytes, developed allergic disease through a mechanism dependent on CD4(+) T cells and the interleukin 4 receptor (IL-4R). Dock2-deficient CD4(+) T cells showed impaired antigen-driven downregulation of IL-4Ralpha surface expression, resulting in sustained IL-4R signaling and excessive T helper type 2 responses. Dock2 was required for T cell receptor-mediated phosphorylation of the microtubule-destabilizing protein stathmin and for lysosomal trafficking and the degradation of IL-4Ralpha. Thus, Dock2 links T cell receptor signals to downregulation of IL-4Ralpha to control the lineage commitment of CD4(+) T cells. |
