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Allele : Gnai2<tm1Lbi> G protein subunit alpha i2; targeted mutation 1, Lutz Birnbaumer
Primary Identifier  MGI:2152603 Allele Type  Targeted
Attribute String  Null/knockout Gene  Gnai2
Transmission  Germline Strain of Origin  129S7/SvEvBrd-Hprt1<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin resistance cassette was inserted into exon 3. The truncated protein is predicted to be inactive and also lack the cysteine at position 352 which is ADP-ribosylated by pertussis toxin. No protein was detected in homogenates from homozygous mice by ADP-ribosylation with pertussis toxin. The absence of protein was also confirmed by immunoblotting.
  • mutations:
  • Insertion
  • synonyms:
  • Gai2<->,
  • Gnai2<tm1Uru>,
  • Gnao1.2<tm1LBi>,
  • Galphai2-,
  • alphai2-,
  • Galphai2-KO,
  • Gnai2<->,
  • Galphai2-,
  • alphai2-,
  • Gai2<->,
  • Gnao1.2<tm1LBi>,
  • Galphai2-KO,
  • Gnai2<tm1Uru>,
  • Gnai2<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

4 Carried By

0 Driven By

80 Publication categories





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