| First Author | Miyagoe Y | Year | 1997 |
| Journal | FEBS Lett | Volume | 415 |
| Issue | 1 | Pages | 33-9 |
| PubMed ID | 9326364 | Mgi Jnum | J:43145 |
| Mgi Id | MGI:1097205 | Doi | 10.1016/s0014-5793(97)01007-7 |
| Citation | Miyagoe Y, et al. (1997) Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: a new model of merosin (laminin 2)-deficient congenital muscular dystrophy. FEBS Lett 415(1):33-9 |
| abstractText | Using the gene targeting technique, we have generated a new mouse model of congenital muscular dystrophy (CMD), a null mutant for the laminin alpha 2 chain, These homozygous mice, designated dy(3K)/dy(3K), characterized by growth retardation and severe muscular dystrophic symptoms and die by 5 weeks of age, Light microscopy revealed that muscle fiber degeneration in these mice begins no later than postnatal day 9. In degenerating muscles, considerable amounts of TUNEL positive nuclei mere detected as well as DNA laddering, suggesting increased apoptotic cell death was involved in the process of muscle fiber degeneration, (C) 1997 Federation of European Biochemical Societies. |
